Maisto papildas nėščiosioms UNO Active Folate Omega DHA

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Prekė: Maisto papildas nėščiosioms UNO Active Folate Omega DHA. Kategorija: Vitaminų ir mineralų papildai.

• Gamintojas: Prenatal
• Modelis: 5904161800934
• Svoris: 41 g

Prenatal UNO Active Folate Omega DHA Acids And Pregnancy Trimester

Nutropharma

Indications and properties:

Prenatal® uno is a preparation especially recommended for women who are in the first trimester of pregnancy. It consists of important ingredients in recommended portions, which supplement the diet, positively affect the course of pregnancy** and fetal development***. Contains i.a. DNA Protection Formula® – a set of ingredients that protect the genetic material (DNA) of the embryo (choline, folate, B12, B6) (1-5). Prenatal® uno also contains a high portion of DHA, an ingredient particularly important for the proper development of the child*** and EPA, affecting the transport of DHA to the placenta (6).

Scientific data: Studies in pregnant women indicate that combined DHA and methylfolate supplementation affects the number of placental cells(7). Scientific reports highlight the role of DHA in placental blood vessel formation during the first trimester of pregnancy, which affects its course(8).

Folian + MethylB12 + vitamin B6 + choline = maximum use of folate(9)

• DNA protection

The results indicate a significant role of choline in protection against DNA damage (1-3) and in the functioning of the central nervous system, including structures responsible for memory(1)(10).

The latest recommendations from 2022 from the USA identify choline as a substance necessary for brain development and highlight the role as an ingredient that can reduce the likelihood of Down syndrome, autism and neural tube defects (WCN)(11).

• Support for proper child development***

Vitamin D in the recommended daily dose of 2000 j.m.(12) is important for ***proper growth and development of bones in children and supports the proper functioning of the immune system.

Iodine helps in the proper production of hormones and the functioning of the thyroid gland. It is important for ***proper growth of children and plays a role in the development and functioning of the nervous system and cognitive functions in children(13).

DHA is essential for the development of the child’s nervous system. Its delivery during pregnancy is particularly important for the development of the brain and retina of the baby's eye***. 200 mg DHA per day as an addition to the recommended intake of 250 mg DHA and EPA per day.

Supplementing the diet with DHA from the beginning of pregnancy has a positive effect on the saturation of mother's tissues. DHA should be supplied in its finished form, since the human body has a limited capacity to synthesize it.(14) The main source of DHA are fatty sea fish, which, according to research, are consumed in too little by women in Poland. (15)

Folian contributes to the growth of maternal tissues during pregnancy**.

Choline, MethylB12, vitamin B6 and folate support homocysteine metabolism, which affects the development of the nervous system of the child (16-18).

• Relieving nausea during pregnancy

Ginger is a natural ingredient with the effect of relieving nausea and nausea in pregnant women, which is confirmed by the results of the study(19).

• Metabolic active forms of vitamins

Calcium L-methylfolate is a form of folate (folic acid) that does not require metabolic activation and is directly used by the mother and fetus(20). Consumption of the active form of folate is important for the general population, especially women with slower folic acid metabolism. This applies to every second Polish woman (12).

Pyridoxal 5-phosphate (B6) and methylcobalamin (MetylB12) are forms of vitamins ready for use by the body(21).

Scientific data does not constitute health claims. EU law prohibits the making of claims regarding the effects of certain substances on human health. Therefore, we do not make such health claims. However, we provide reliable research carried out on these raw materials so that you can exercise the rights guaranteed in Articles 54 and 73 of the Constitution of the Republic of Poland: the freedom to receive information and the freedom to use the results of scientific research.

1. Shaw GM, Carmichael SL, Yang W, Selvin S, Schaffer DM. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol. 2004;160(2):102–9.

2. Zeisel SH. Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health. 2013;5:193–9.

3. Zeisel SH. Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat Res Mol Mech Mutagen. 2012 May 1;733(1–2):34–8.

4. Wang X, Yu J, Wang J. Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective? Int J Mol Sci. 2023;24(3).

5. Petersen JM, Parker SE, Crider KS, Tinker SC, Mitchell AA, Werler MM. One-Carbon Cofactor Intake and Risk of Neural Tube Defects among Women Who Meet Folic Acid Recommendations: A Multicenter Case-Control Study. Am J Epidemiol. 2019;188(6):1136–43.

6. Larque E, et al. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Am J Clin Nutr. 2006;84(4):853–61.

7. Klingler M, Blaschitz A, Campoy C, Caño A, Molloy AM, Scott JM, et al. The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. Br J Nutr. 2006;96(01):182.

8. Basak S, Das MK, Duttaroy AK. Fatty acid-induced angiogenesis in first trimester placental trophoblast cells: Possible roles of cellular fatty acid-binding proteins. Life Sci [Internet]. 2013;93(21):755–62

9. Drews K. Active support of the folate pathway - Epigenetic effect of choline and vitamin B12 on pregnancy development. Ginekol Pol. 2015;86(12):940–6.

10. Zeisel SH. Choline: Needed for Normal Development of Memory. J Am Coll Nutr. 2000;19:528S-531S.

11. Adams JB, Kirby JK, Sorensen JC, Pollard EL, Audhya T. Evidence based recommendations for an optimal prenatal supplement for women in the US: vitamins and related nutrients. Matern Heal Neonatol Perinatol. 2022;8(1):1–37.

12. Seremak-Mrozikiewicz A. The importance of folate metabolism in the development of complications in pregnant women. Ginekol Pol. 2013;84(5):377–84.

13. Hynes KL, Otahal P, Hay I, Burgess JR. Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort. J Clin Endocrinol Metab. 2013;98(5):1954–62.

14. Lauritzen L, Brambilla P, Mazzocchi A, Harsløf LBS, Ciappolino V, Agostoni C. DHA effects in brain development and function. Nutrients. 2016;8(1):1–17.

15. Position of the Expert Group on supplementation of docosahexaenoic acid and other omega-3 fatty acids in the population of pregnant women, breastfeeding women and infants and children up to 3 years of age. Pediatrician Pol 2010;85(6): 597-603.

16. Mills JL, Scott JM, Kirke PN, McPartlin JM, Conley MR, Weir DG, Molloy AM, Lee YJ. Homocysteine and neural tube defects. J Nutr. 1996 Mar;126(3):756S-760S. doi: 10.1093/jn/126.suppl_3.756S.

17. Peker E, Demir N, Tuncer O, Üstyol L, Balahoroğlu R, Kaba S, et al. The levels of vitamán B12, folate and homocysteine in mothers and their babies with neural tube defects. J Matern Neonatal Med. 2016;29(18):2944–8.

18. Gu Q, Li Y, Cui ZL, Luo XP. Homocysteine, folate, vitamin B12 and B6 in mothers of children with neural tube defects in Xinjiang, China. Acta Paediatr Int J Paediatr. 2012;101(11):486–90.

19. Saberi F, Sadat Z, Abedzadeh-Kalahroudi M, Taebi, Mahboobeh. Effect of Ginger on Relieving Nausea and Vomiting in Pregnancy: A Randomized, Placebo-Controlled Trial. Nurs Midwifery Stud. 2014 Apr 17;3(1):11841.

20. Ferrazzi E, Tiso G, Di Martino D. Folic acid versus 5-methyl tetrahydrofolate supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2020;253:312–9.

21. Jarosz M, Rychlik E, Stoś K, Charzewska J. Nutrition standards for the Polish population and their application. NIZP-PZH; 2020.

• Product Certificate: NQS, Eurofins, Polish Quality Award

• Recommended by PTGiP
• In the first trimester of pregnancy
• Only active Folian
• Now with DHA
• Support for proper child development***
• DNA Protection Formula® – a set of ingredients that protect the germ’s genetic material (DNA) (choline, folate, B12, B6)(1-5)

Vitamin-mineral capsule:

Active ingredients in a daily portion: 1 capsule GINGER (ZINGIBER OFFICINALE) (RHIZOME) IN THE FORM OF 20:1 EXTRACT, WHICH EQUIVALENT TO 600 MG RAW MATERIAL 30 mg Choline (choline bitartrate) 125 mg (200%)* Folic acid Folate 800 μg (400%)* Iodine (potassium iodide) 150 μg (100%)* Vitamin D3 (cholecalciferol) 50 μg/2000 jm (1000%)* Vitamin B6 (pyridoxal-5-phosphate) 1.25 mg (89.3%)* Vitamin B12 (MethylB12 - methylcobalamin) 1 μg (40%)* *percentage of reference intake values.

Ingredients of the vitamin-mineral capsule: choline bitartrate, rice meal, capsule: gelatin; extract of im­bir, cholecalciferol, anti-caking agents: magnesium salts of fatty acids, silicon dioxide; pyridoxide­salo-5-phosphate, methylcobalamin, calcium L-methylfolate (folate), potassium iodide.

DHA capsule:

Active ingredients in a daily portion 1 capsule Vitamin E (D-alpha tocopherol) 7,8 mg (65%)1 DHA (docosahexaenoic acid from fish oil 300 mg (50-75%)2 EPA (eicosapentaenoic acid from fish oil 63 mg 1 percent of the reference intake values

2 percent implementation of recommendations according to the recommendation: Pediatrician Pol. 2010;85(6):597-603; Ginekol Pol. 2014;85(4):318-20

Ingredients of DHA capsule: fish oil (anchovies, sardines, mackerel), capsule: beef gelatin; D-alpha-tocopherol.

Specifications

Group	Name	Value
Parametry	Condition	new
Parametry	Invoice	With VAT invoice
Parametry	Manufacturer code	5904161800934
Parametry	Brand	Prenatal
Parametry	Name	other (Prenatal Uno kaps. 30kaps. (+ 30 kaps.))
Parametry	For	for women
Parametry	Form	capsules
Parametry	Number of pieces	60 pcs
Parametry	Volume	30 ml
Parametry	Basic ingredient	folic acid
Parametry	Product weight with unit packaging	0.034 kg
Parametry	EAN (GTIN)	5904161800934
Parametry	Packaging status	original
Parametry	Expiration date	at least 1 year from the date of purchase
Parametry	Flavor	advocaat
Parametry	Weight	41 g
Parametry	Number of servings per packaging	30
Parametry	Additional features	safe for pregnant women,unscented,protect from light