{"product_id":"maisto-papildas-aliness-methylofolian-600mcg-vitaminas-b9-100-kapsuliu","title":"Maisto papildas Aliness MethyloFolian 600mcg, vitaminas B9, 100 kapsulių","description":"\u003ch2\u003eTrumpai apie prekę\u003c\/h2\u003e\u003cp\u003ePrekė: Maisto papildas Aliness MethyloFolian 600mcg, vitaminas B9, 100 kapsulių. Kategorija: Aminorūgštys.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGamintojas:\u003c\/strong\u003e Aliness\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eModelis:\u003c\/strong\u003e 5902596935641\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSvoris:\u003c\/strong\u003e 150 g\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e1081 µg 5-MTHF, including 600 µg folic acid\u003c\/h2\u003e\n\u003ch2\u003e100 capsules Vege Caps for 100 days\u003c\/h2\u003e\n\u003cp\u003eMETHYLO FOLIAN 600 µg by ALINESS is a natural source of folate in the patented form of Quaterfolic®.\u003c\/p\u003e\n\u003cp\u003eThe consumption of folate in the diet is often insufficient. The reason is that natural folates are susceptible to oxidation, rapidly lose activity in food and are largely, up to 90%, destroyed by cooking. In addition, they are characterized by low and incomplete bioavailability.\u003c\/p\u003e\n\u003cp\u003eMost of the folate you take comes from an artificial version of folic acid in supplements and added to foods. Synthetic folic acid is inactive and must be metabolized in the body to 5-methyltetrahydrofolate (5-MTHF) to become metabolically effective.\u003c\/p\u003e\u003cp\u003eToday, we know that folic acid undergoes complex metabolism and that people taking folic acid may still have severe folate deficiency due to large differences in how effectively folic acid is converted into a bioactive form in different people.\u003c\/p\u003e\n\u003cp\u003eThe high solubility of Quatrefolic® in water means that it can be better absorbed by mucosal cells that facilitate access to blood and circulation, with the possibility of improving bioavailability.\u003c\/p\u003e\n\u003cp\u003eDue to the fact that Quatrefolic® contains a metabolically reduced form of folate, used and stored in the human body, it is completely bioavailable, exhibits extraordinary, long-term chemical stability.\u003c\/p\u003e\n\u003ch2\u003eQUATERFOLIC® IS THE ACTIVE, NATURAL AND MOST BIOAVAILABLE FORM OF FOLATE\u003c\/h2\u003e\n\u003ch2\u003ePregnancy \/ lactation:\u003c\/h2\u003e\n\u003cp\u003eIncreased demand for folate occurs during very active growth of body cells, such as during pregnancy and lactation. . Quatrefolic® as a source of (6S)-5-methyltetrahydrofolate (5-MTHF) may be particularly useful in providing a nutritionally active form of folate in the period before conception, during pregnancy and lactation. Folate concentrations in breast milk are maintained at the expense of its reserves in the mother's body. A nursing woman needs 128 μg per day of additional folate to replenish her losses. 5-MTHF has been shown to be effective and perhaps more effective than folic acid in maintaining folate concentrations in erythrocytes during lactation.\u003c\/p\u003e\n\u003ch2\u003eInfants and children:\u003c\/h2\u003e\n\u003cp\u003eFolate is a critical nutrient when cell growth in the body is very active and folate deficiency can slow down overall growth. It helps in the proper functioning of the immune system.\u003c\/p\u003e\n\u003ch2\u003eAdults:\u003c\/h2\u003e\n\u003cp\u003eFolate is involved in the production of key neurotransmitters in the brain, and its absence may contribute to disorders of psychological functions. Folate is a cofactor in many important biological reactions, and its deficiency can occur at all stages of life. Folate supplementation can improve quality of life by reducing fatigue and fatigue\u003c\/p\u003e\n\u003ch2\u003eElderly people:\u003c\/h2\u003e\n\u003cp\u003eFolate deficiency occurs in approx. 30% of the older population. Folate supplementation is important in older people because with age, the level of homocysteine in the blood rises and its metabolism depends on folate. As part of the aging process, numerous physical and physiological changes occur. Aging is associated with changes in the functioning of the gastrointestinal tract, which may possibly affect the absorption of various forms of folate. Supplementation of folate with high bioavailability, especially in this age group, allows you to support proper psychological functions such as concentration, memory and learning.\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003ehelp in the proper production of blood\u003c\/li\u003e\n\u003cli\u003ehelp maintain normal homocysteine metabolism\u003c\/li\u003e\n\u003cli\u003ehelp maintain normal psychological functions\u003c\/li\u003e\n\u003cli\u003econtribute to the reduction of tiredness and fatigue\u003c\/li\u003e\n\u003cli\u003ehelp in the proper functioning of the immune system\u003c\/li\u003e\n\u003cli\u003eparticipate in the process of cell division\u003c\/li\u003e\n\u003cli\u003ehelp in the proper synthesis of amino acids\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eMost of the folate you take comes from the synthetic version of folic acid in supplements and added to foods\u003c\/p\u003e\n\u003cp\u003eToday we know that folic acid undergoes complex metabolism and that among the population there are differences in the ability to effectively metabolize folic acid into its bioactive form (1,2).\u003c\/p\u003e\n\u003cp\u003eFolates in food are hydrolyzed to a form of monoglutamate in the intestine before being absorbed by active transport through the intestinal mucosa. Therefore, before entering the bloodstream, the form of monoglutamate is reduced to tetrahydrofolate (THF) and converted into methyl forms.\u003c\/p\u003e\n\u003cp\u003eOn the other hand, folic acid is first reduced to dihydrofolate by the enzyme dehydrofolate reductase (DHFR), and then to tetrahydrofolate. In humans, the gut appears to have very high ability to convert reduced folates from food into 5-MTHF, but limited ability to reduce folic acid. In fact, it reaches the liver in an unmetabolized form.\u003c\/p\u003e\n\u003cp\u003eQuatrefolic®, a highly bioavailable form of folate, may be the best choice when it comes to supplementing with active folate to support and regulate the methylation cycle. (7,8).\u003c\/p\u003e\n\u003ch2\u003eQuaterfolic® -NATURAL SOURCE OF FOLIC ACID, ACTIVE FORM OF FOLATE\u003c\/h2\u003e\n\u003cp\u003eQuatrefolic® passes through the stomach barrier and is absorbed mainly in the small intestine through the carrier mechanism.\u003c\/p\u003e\n\u003cp\u003eThe biotransformation of folic acid to 5-MTHF in the liver is regulated by two polymorphic enzymes, DHFR and MTHFR. DHFR activity appears to be low and highly variable. Chronic exposure of the liver to folic acid can cause saturation with this component, which can cause systemic circulation of unmetabolized folic acid. In addition, some people experience genetic changes that reduce DHFR activity.\u003c\/p\u003e\n\u003cp\u003eA new study published in 2014 clearly indicated that 86% of folic acid in the hepatic portal vein is unmetabolized, with almost all of the natural folate being converted correctly (3,4). .\u003c\/p\u003e\n\u003ch2\u003eQuaterfolic® - BIOAVAILABILITY\u003c\/h2\u003e\n\u003cp\u003eThe oral bioavailability of the active ingredient is highly dependent on its solubility. Absorption of the compound occurs after dispersion and dissolution in the fluid in the intestines.\u003c\/p\u003e\n\u003ch2\u003eWhat does solubility mean?\u003c\/h2\u003e\n\u003cp\u003eHigh water solubility means Quatrefolic® can be better absorbed by mucosal cells that facilitate access to blood and circulation.\u003c\/p\u003e\n\u003cp\u003eHigh water solubility means that Quatrefolic® can be easily absorbed by mucosal cells that facilitate access to blood and circulation, with the ability to improve the bioavailability of this chemical form of folate.\u003c\/p\u003e\n\u003cp\u003eThe extremely high solubility of Quatrefolic® in water is due to two specific characteristics of the component: the glucosamine-forming agent and the amorphous chemical structure of the product\u003c\/p\u003e\n\u003cp\u003eThe amorphous state provides inseparably related solubility, guaranteeing a homogeneous and reproducible dissolution process, while the crystalline alternative cannot provide this.\u003c\/p\u003e\n\u003ch2\u003eQuaterfolic® -STABILITY\u003c\/h2\u003e\n\u003cp\u003eQuatrefolic® exhibits extraordinary, long-term chemical stability guaranteeing completely unchanged purity even after a few months, and reduction from analysis within 18 months less than 1%, which allows easy application and storage. The pH value of Quatrefolic after reconstitution is neutral. This value also provides higher stability to the molecule, protecting it from hydrolytic degradation.\u003c\/p\u003e\n\u003cp\u003eThe stability of Quatrefolic® powder has been tested in accordance with the ICH (International Council for the Harmonisation of Technical Requirements for the Registration of Medicinal Products for Human Use) guidelines both at room temperature and under other storage conditions for samples in airtight containers protecting against light, and with the measurement of purity and result at different points.\u003c\/p\u003e\n\u003cp\u003eMedicaline has deliberately decided to conduct Quatrefolic® stability tests in accordance with the strictest guidelines, required specifically for pharmaceutical ingredients, guaranteeing independent and reliable criteria in order to make a statement of long-term chemical stability before starting the promotion of the product to its customers.\u003c\/p\u003e\n\u003cp\u003eThe lyophilised component can be used without special and restrictive conditions, easily combined with other ingredients and reagents, and can be stored at room temperature instead of at 2 to 8°C, like other folate derivatives\u003c\/p\u003e\n\u003cp\u003eCapsule content -1 capsule % RWS* \/daily portion:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eCalcium L-methylfolate\u003c\/b\u003e (5-MTHF): 1081 µg\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e-including folic acid \u003c\/b\u003e600 µg 300%*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e*RWS: daily reference intake for adults. Reference intake for the average adult (8400 kJ\/ 2000 kcal)\u003c\/p\u003e\n\u003cp\u003ebulking agent: microcrystalline cellulose, 5-MTHF calcium L-methylfolate (glucosamine salt), glazing agent (capsule shell): hydroxypropylcellulose\u003c\/p\u003e\u003ch2\u003e\u003cb\u003eDosage: \u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e1 capsule a day, during a meal.\u003c\/p\u003e\n\u003ch2\u003eContents of the pack:\u003c\/h2\u003e\n\u003cp\u003e100 vegetarian capsules\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eManufacturer: \u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eMedicaline\u003c\/p\u003e\n\u003ch2\u003eStorage:\u003c\/h2\u003e\n\u003cp\u003eStore at room temperature out of reach of small children.\u003c\/p\u003e\n\u003ch2\u003eThe product cannot be used as a substitute for a varied diet.\u003c\/h2\u003e\n\u003ch2\u003eA balanced diet and a healthy lifestyle are the basis for the proper functioning of the body. Do not exceed the recommended portion for consumption during the day. \u003cb\u003eDietary supplement.\u003c\/b\u003e\n\u003c\/h2\u003e\n\n\u003cp\u003e\u003cb\u003e1. \u003c\/b\u003e Smith DA et al. Is folic acid good for everyone? Am J Clin Nutr. 2008\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2. \u003c\/b\u003e Bailey SW, Ayling JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proceedings of the National Academy of Sciences of the United States of America. 2009\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e3. \u003c\/b\u003e Petrik K et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4. \u003c\/b\u003e Patanwala I and Others. Folic acid handling by the human gut: implications for food fortification and supplementation. Am J Clin Nutr. 2014\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5. \u003c\/b\u003e van der Put NMJ and others. A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects? Am. J. Hum. Genet. 1998\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e6. \u003c\/b\u003e Meshkin B, Blum K. Folate nutrigenomics: a convergence for dietary folate metabolism, folic acid supplementation, and folate antagonist pharmacogenetics. Drug Metab Lett. 2007\u003c\/p\u003e\n\u003cp\u003e7. Bailey LB et al. Folate metabolism and requirements. J Nutr. 1999\u003c\/p\u003e\n\u003cp\u003e8. Scott JM, Weir DG. Folic acid, homocysteine and one carbon metabolism: a review of the essential biochemistry. J Cardiovasc Risk. 1998\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eGroup\u003c\/th\u003e\n\u003cth\u003eName\u003c\/th\u003e\n\u003cth\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eCondition\u003c\/td\u003e\n\u003ctd\u003enew\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eInvoice\u003c\/td\u003e\n\u003ctd\u003eWith VAT invoice\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eManufacturer code\u003c\/td\u003e\n\u003ctd\u003e5902596935641\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eBrand\u003c\/td\u003e\n\u003ctd\u003eAliness\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eKind\u003c\/td\u003e\n\u003ctd\u003emulti-component product\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eFlavor\u003c\/td\u003e\n\u003ctd\u003eflavorless\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eForm\u003c\/td\u003e\n\u003ctd\u003ecapsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eFeatures\u003c\/td\u003e\n\u003ctd\u003evegan\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eWeight\u003c\/td\u003e\n\u003ctd\u003e150 g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eNumber of pieces in the package\u003c\/td\u003e\n\u003ctd\u003e100 pcs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eVolume\u003c\/td\u003e\n\u003ctd\u003e100 ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eNumber of servings per packaging\u003c\/td\u003e\n\u003ctd\u003e100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eExpiration date\u003c\/td\u003e\n\u003ctd\u003enot specified\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eProduct weight with unit packaging\u003c\/td\u003e\n\u003ctd\u003e0.07 kg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003eEAN (GTIN)\u003c\/td\u003e\n\u003ctd\u003e5902596935641\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eParametry\u003c\/td\u003e\n\u003ctd\u003ePackaging status\u003c\/td\u003e\n\u003ctd\u003eoriginal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"vigor4u","offers":[{"title":"Default Title","offer_id":46050797551676,"sku":"15425295697","price":30.36,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0618\/2161\/6188\/files\/Aliness-MethyloFolian-600mcg-FOLIC-ACID-VITAMIN-B9-NERVOUS-SYSTEM-100caps.jpg?v=1787552599","url":"https:\/\/market365.lt\/de\/products\/maisto-papildas-aliness-methylofolian-600mcg-vitaminas-b9-100-kapsuliu","provider":"Market365","version":"1.0","type":"link"}